MMEL1

Across TCGA patient cohorts, MMEL1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMEL1-associated genes across cancer lineages are ATM, Stathmin, and mTOR_pS2448. Each is linked with MMEL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMEL1-to-partner and partner-to-MMEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MMEL1-low versus MMEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMEL1→partner) and Y-score (partner→MMEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.520	-2.874	.001	<.001	3	4
COAD	Stathmin →	+0.143	+2.178	.047	.035	3	3
UCEC	mTOR_pS2448 →	-0.163	-2.886	.001	.001	3	3
UCEC	Shc_pY317 →	-0.141	-2.000	.008	.029	3	3
UCEC	ASNS →	+0.442	+2.087	<.001	.005	3	3
UCEC	4E-BP1 →	+0.303	+3.700	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by MMEL1 expression — UCEC

Explore this box plot interactively →