MMEL1

Across TCGA pan-cancer cohorts, MMEL1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MMEL1 data layer compared with 7 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher MMEL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MMEL1 expression acts as an unfavorable survival marker, although some lineages such as MESO and BLCA show a favorable association.

MESO, LGG, and BLCA are the cancer types where MMEL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.495	0.279	<.001	81	view →
LGG	DFS	Median	All	0.642	0.840	<.001	53	view →
BLCA	DFS	Median	IV	0.625	0.291	.005	44	view →
UCS	OS	Tertile	IV	0.224	0.883	.024	30	view →
ACC	DFS	Median	III,IV	0.734	0.395	.008	25	view →
BRCA	DFS	Quartile	III,IV	0.888	0.697	.003	22	view →
PAAD	OS	Quartile	All	0.293	0.546	.009	21	view →
READ	DFS	Median	IV	0.936	0.179	.010	21	view →
CESC	DFS	Quartile	All	0.652	0.876	<.001	20	view →
KIRC	DFS	Quartile	III,IV	0.659	0.840	.013	16	view →
SKCM	DFS	Tertile	IV	0.562	0.043	.004	13	view →
LUAD	DFS	Tertile	All	0.747	0.544	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MMEL1–MESO (OS)

Open the MESO breakdown →