MMEL1

Across TCGA pan-cancer cohorts, MMEL1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MMEL1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MMEL1 RNA is repressed in tumor relative to normal tissue. In most cancer types MMEL1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LUSC are the cancer types where MMEL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMEL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.327	<.001	10	view →
KIRC	Female	II,III,IV	−0.732	<.001	10	view →
LUSC	Male	II,III,IV	−0.719	<.001	7	view →
HNSC	All	IV	−0.480	.003	7	view →
BRCA	Female	All	+0.638	<.001	6	view →
CHOL	All	II,III,IV	+1.609	.008	4	view →
PAAD	All	All	+1.414	.011	4	view →
BLCA	All	All	+0.658	.020	4	view →
LUAD	Male	III,IV	−0.488	<.001	4	view →
LIHC	Female	II,III,IV	+0.172	<.001	3	view →
KICH	Female	All	−0.771	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MMEL1–THCA

Open the THCA breakdown →