MMEL1

Across TCGA cell cohorts, MMEL1 mutation is significantly associated with the RNA expression of many other genes, with 557 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMEL1-associated genes across cancer lineages are KSR2, TMEM244, and RETREG1. Each is linked with MMEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMEL1-to-partner and partner-to-MMEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by MMEL1-low versus MMEL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMEL1→partner) and Y-score (partner→MMEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KSR2 →	+0.302	+4.283	.001	<.001	3	2
BLOOD_Lymphoma	TMEM244 →	+0.727	+3.727	<.001	.005	3	2
LARGE_INTESTINE	RETREG1 →	+1.031	+2.502	.009	.005	3	2
LARGE_INTESTINE	RPL22L1 →	+1.269	+3.169	.002	.009	3	2
LARGE_INTESTINE	OR4F21 →	+0.082	+2.234	.004	.002	3	2
LARGE_INTESTINE	C17orf97 →	+1.003	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 557 associations by consensus.

KSR2 by MMEL1 expression — BLOOD_Leukemia

Explore this box plot interactively →