MMADHC

Across TCGA patient cohorts, MMADHC mutation is significantly associated with the RNA expression of many other genes, with 2,087 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMADHC-associated genes across cancer lineages are RNU6-1233P, RN7SKP120, and RNY1P1. Each is linked with MMADHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMADHC-to-partner and partner-to-MMADHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1233P grouped by MMADHC-low versus MMADHC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMADHC→partner) and Y-score (partner→MMADHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1233P →	+0.653	+7.816	<.001	.008	3	2
SKCM	RN7SKP120 →	+0.108	+7.816	<.001	.008	3	2
UCEC	RNY1P1 →	+0.211	+3.428	<.001	<.001	3	2
UCEC	RNU6-1228P →	+0.134	+3.634	.005	.001	3	2
COAD	RN7SL291P →	+0.307	+6.392	.008	.001	3	2
COAD	RNU4-54P →	+1.308	+6.392	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,087 associations by consensus.

RNU6-1233P by MMADHC expression — SKCM

Explore this box plot interactively →