MMACHC

Across TCGA patient cohorts, MMACHC RNA expression is significantly associated with the protein abundance of many other proteins, with 15,895 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MMACHC-associated proteins across cancer lineages are PAF1, NASP, and ZMYM4_S122. Each is linked with MMACHC in more than 5 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MMACHC versus PAF1 in COAD, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAF1 →	+0.269	+0.616	<.001	<.001	3	6
BRCA	NASP →	+0.468	+0.366	<.001	<.001	3	6
OV	ZMYM4_S122 →	+0.678	+0.555	<.001	<.001	3	6
BRCA	YTHDF2 →	+0.275	+0.518	<.001	<.001	3	6
PDAC	SNX9 →	-0.210	-0.300	<.001	<.001	3	6
UCEC	CDC20_T70 →	+0.844	+0.434	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,895 associations by consensus.

MMACHC vs PAF1 — COAD

Explore this scatter interactively →