MMACHC

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MMACHC protein abundance is significantly associated with the protein abundance of many other proteins, with 8,194 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MMACHC-associated proteins across cancer lineages are CSK, BAZ2A_S1783, and CCNA2. Each is linked with MMACHC in more than 2 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MMACHC versus CSK in LSCC, with a Pearson correlation of -0.37.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCCSK →-0.295-0.340.002.00332
LSCCBAZ2A_S1783 →+0.746+0.409.001.00132
COADCCNA2 →+1.087+0.817<.001<.00132
COADABCD1 →-1.161-0.908.001<.00132
COADDNPEP →-0.530-0.709.003.00132
COADGAS2L1_S479 →+1.054+0.747<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 8,194 associations by consensus.

MMACHC vs CSK — LSCC

Per-sample scatter of MMACHC vs CSK in LSCC (Pearson r = -0.37).

Explore this scatter interactively →

Exploration