MMACHC

Across TCGA patient cohorts, MMACHC mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMACHC-associated genes across cancer lineages are EGFR_pY1068, ERK2, and GAPDH. Each is linked with MMACHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MMACHC-low versus MMACHC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.321	.024	.034	3	2
UCEC	ERK2 →	+0.238	+3.169	.006	.018	3	1
UCEC	GAPDH →	+0.522	+2.999	.031	.035	3	1
UCEC	JNK2 →	+0.224	+2.000	.012	.032	3	1
UCEC	MEK1 →	+0.498	+3.169	.002	.018	3	1
UCEC	MSH2 →	-0.281	-2.973	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by MMACHC expression — UCEC

Explore this box plot interactively →