MMACHC

Across TCGA cell cohorts, MMACHC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,439 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MMACHC-associated GO terms across cancer lineages are 'de novo' IMP biosynthetic process, IMP biosynthetic process, and mRNA alternative polyadenylation. Each is linked with MMACHC in more than 15 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' IMP biosynthetic process grouped by MMACHC-low versus MMACHC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	'de novo' IMP biosynthetic process →	+0.158	+0.803	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	IMP biosynthetic process →	+0.182	+0.887	<.001	.001	3	15
URINARY_TRACT	mRNA alternative polyadenylation →	+0.110	+0.963	<.001	<.001	3	14
LIVER	Ribosomal large subunit assembly →	+0.119	+1.146	.001	<.001	3	14
LIVER	Regulation of translational fidelity →	+0.116	+0.927	.005	.001	3	14
OESOPHAGUS	Demethylation →	+0.153	+0.973	<.001	<.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,439 associations by consensus.

'de novo' IMP biosynthetic process by MMACHC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →