MMACHC

Across TCGA cell cohorts, MMACHC mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MMACHC-associated genes across cancer lineages are SLC32A1, PANX3, and DEFB108B. Each is linked with MMACHC in more than 1 cancer types. Because this analysis shows association rather than direction, both MMACHC-to-partner and partner-to-MMACHC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by MMACHC-low versus MMACHC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMACHC→partner) and Y-score (partner→MMACHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.505	+3.901	.003	.006	3	1
BLOOD_Leukemia	PANX3 →	+0.243	+4.180	<.001	.003	3	1
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	1
BLOOD_Leukemia	MORN5 →	+0.282	+3.855	<.001	.007	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SLC32A1 by MMACHC expression — BLOOD_Leukemia

Explore this box plot interactively →