MLXIPL

Across TCGA cell cohorts, MLXIPL mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLXIPL-associated genes across cancer lineages are FABP12, C9orf92, and TAS2R9. Each is linked with MLXIPL in more than 1 cancer types. Because this analysis shows association rather than direction, both MLXIPL-to-partner and partner-to-MLXIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP12 grouped by MLXIPL-low versus MLXIPL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLXIPL→partner) and Y-score (partner→MLXIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FABP12 →	+0.124	+5.169	<.001	<.001	3	2
SKIN	C9orf92 →	+0.077	+3.347	.002	.005	3	2
LUNG_NSCLC_LUAD	TAS2R9 →	+0.057	+3.695	<.001	.005	3	2
BLOOD_Myeloma	CLRN1 →	+0.175	+3.906	.003	.009	3	1
BLOOD_Myeloma	VNN3 →	+0.045	+4.754	<.001	<.001	3	1
OESOPHAGUS	SCGB3A2 →	+0.688	+4.017	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FABP12 by MLXIPL expression — SOFT_TISSUE

Explore this box plot interactively →