MLXIPL

Across TCGA pan-cancer cohorts, MLXIPL RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MLXIPL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MLXIPL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MLXIPL is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

COAD, THCA, and BRCA are the cancer types where MLXIPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLXIPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+3.554	<.001	11	view →
THCA	Male	II,III,IV	+1.708	<.001	10	view →
BRCA	All	III,IV	−2.688	<.001	8	view →
LUAD	Male	All	−1.209	<.001	8	view →
KIRP	All	III,IV	−1.271	.004	6	view →
HNSC	All	All	−0.680	.001	6	view →
KIRC	Male	II,III,IV	+0.867	.007	5	view →
CHOL	Male	All	−3.210	<.001	4	view →
STAD	All	All	+1.562	<.001	4	view →
KICH	All	All	−0.887	.006	4	view →
LIHC	Male	All	+0.835	<.001	4	view →
READ	Female	All	+2.883	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MLXIPL–COAD

Open the COAD breakdown →