MLN

Across TCGA patient cohorts, MLN mutation is significantly associated with the RNA expression of many other genes, with 625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLN-associated genes across cancer lineages are RPS3AP17, IGKV1D-12, and RNU6-745P. Each is linked with MLN in more than 1 cancer types. Because this analysis shows association rather than direction, both MLN-to-partner and partner-to-MLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP17 grouped by MLN-low versus MLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLN→partner) and Y-score (partner→MLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS3AP17 →	+0.103	+3.192	<.001	<.001	3	2
UCEC	IGKV1D-12 →	+1.139	+4.180	.002	<.001	3	1
LUSC	RNU6-745P →	+0.407	+4.748	<.001	.003	3	1
LUSC	RNU6-371P →	+0.269	+6.102	<.001	.001	3	1
LUSC	RNU6-12P →	+0.355	+4.591	.004	.004	3	1
LUSC	LINC00676 →	+0.947	+5.989	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 625 associations by consensus.

RPS3AP17 by MLN expression — UCEC

Explore this box plot interactively →