MLN

Across TCGA pan-cancer cohorts, MLN RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MLN data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher MLN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MLN expression acts as an unfavorable survival marker, although some lineages such as CESC and LUAD show a favorable association.

MESO, BRCA, and LIHC are the cancer types where MLN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.282	0.442	.002	85	view →
BRCA	DFS	Median	IV	0.460	0.951	.001	61	view →
LIHC	OS	Tertile	II,III,IV	0.423	0.661	.006	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
CESC	OS	Tertile	II,III,IV	0.871	0.461	.012	30	view →
SARC	DFS	Quartile	All	0.384	0.588	<.001	29	view →
ACC	DFS	Quartile	All	0.364	0.729	.004	26	view →
KIRC	DFS	Quartile	IV	0.187	0.377	.010	25	view →
STAD	DFS	Tertile	III,IV	0.270	0.496	.014	20	view →
UCEC	DFS	Tertile	All	0.743	0.857	.002	18	view →
KIRP	OS	Tertile	III,IV	0.170	0.564	.029	12	view →
LUAD	OS	Tertile	III,IV	0.797	0.616	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MLN–MESO (DFS)

Open the MESO breakdown →