MLLT1

Across TCGA patient cohorts, MLLT1 mutation is significantly associated with the RNA expression of many other genes, with 3,442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLLT1-associated genes across cancer lineages are RN7SKP11, CCL5, and RN7SL248P. Each is linked with MLLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT1-to-partner and partner-to-MLLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP11 grouped by MLLT1-low versus MLLT1-high in UCS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT1→partner) and Y-score (partner→MLLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	RN7SKP11 →	+0.513	+5.700	<.001	.002	3	2
UCEC	CCL5 →	+0.886	+1.776	.001	<.001	3	2
UCEC	RN7SL248P →	+0.049	+2.768	<.001	.002	3	2
UCEC	CCL4 →	+0.668	+1.776	.001	<.001	3	2
UCEC	ELMO2P1 →	+0.089	+1.599	.002	.001	3	2
UCEC	TMEM107 →	+0.375	+2.010	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,442 associations by consensus.

RN7SKP11 by MLLT1 expression — UCS

Explore this box plot interactively →