MLLT1

Across TCGA pan-cancer cohorts, MLLT1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MLLT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MLLT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MLLT1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where MLLT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLLT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.739	<.001	11	view →
THCA	Male	III,IV	−1.138	<.001	10	view →
HNSC	Male	IV	+0.744	<.001	9	view →
LIHC	All	II,III,IV	+0.934	<.001	7	view →
UCEC	All	All	−0.719	<.001	6	view →
BRCA	All	II,III,IV	+0.186	.011	6	view →
LUAD	All	All	−0.541	<.001	5	view →
STAD	Male	II,III,IV	+0.871	.006	4	view →
READ	All	III,IV	+0.769	.018	4	view →
KIRC	All	II,III,IV	−0.270	.004	4	view →
CHOL	Female	All	+2.260	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MLLT1–COAD

Open the COAD breakdown →