MLLT1

Across TCGA cell cohorts, MLLT1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLLT1-associated genes across cancer lineages are C20orf85, OR4D11, and PRAMEF8. Each is linked with MLLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT1-to-partner and partner-to-MLLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by MLLT1-low versus MLLT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT1→partner) and Y-score (partner→MLLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C20orf85 →	+0.022	+3.734	.002	.006	3	1
LUNG_NSCLC_LUAD	OR4D11 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	PRAMEF8 →	+0.012	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE2A →	+0.045	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	C16orf82 →	+0.007	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

C20orf85 by MLLT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →