MKRN3

Across TCGA patient cohorts, MKRN3 mutation is significantly associated with the RNA expression of many other genes, with 4,065 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKRN3-associated genes across cancer lineages are RPS10-NUDT3, LHX5-AS1, and RNU4-84P. Each is linked with MKRN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MKRN3-to-partner and partner-to-MKRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10-NUDT3 grouped by MKRN3-low versus MKRN3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKRN3→partner) and Y-score (partner→MKRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS10-NUDT3 →	+0.200	+1.989	.009	.008	3	4
SKCM	LHX5-AS1 →	+0.025	+2.990	<.001	.006	3	4
CESC	RNU4-84P →	+0.228	+5.584	<.001	.001	3	3
UCEC	NOP10 →	+0.514	+2.415	<.001	<.001	3	3
HNSC	TSPY8 →	+0.124	+3.608	<.001	.002	3	3
STAD	ZMAT1 →	-0.664	-3.296	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,065 associations by consensus.

RPS10-NUDT3 by MKRN3 expression — LUAD

Explore this box plot interactively →