MKRN3

Across TCGA pan-cancer cohorts, MKRN3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MKRN3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MKRN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MKRN3 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where MKRN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKRN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.744	<.001	11	view →
LIHC	Female	All	+0.372	<.001	7	view →
KICH	Male	All	−0.270	<.001	7	view →
BRCA	Female	II,III,IV	+0.463	<.001	6	view →
LUSC	All	II,III,IV	+0.961	<.001	5	view →
LUAD	All	All	+0.232	.001	5	view →
COAD	Female	III,IV	−0.057	.006	3	view →
CHOL	Male	All	+0.055	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MKRN3–HNSC

Open the HNSC breakdown →