MKKS

Across TCGA patient cohorts, MKKS mutation is significantly associated with the RNA expression of many other genes, with 1,002 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MKKS-associated genes across cancer lineages are RNU5E-9P, CD99P1, and RN7SL248P. Each is linked with MKKS in more than 1 cancer types. Because this analysis shows association rather than direction, both MKKS-to-partner and partner-to-MKKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5E-9P grouped by MKKS-low versus MKKS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKKS→partner) and Y-score (partner→MKKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU5E-9P →	+0.208	+4.055	<.001	<.001	3	2
UCEC	CD99P1 →	+0.364	+2.624	.003	.005	3	2
UCEC	RN7SL248P →	+0.068	+3.307	<.001	.003	3	2
UCEC	RNA5SP411 →	+1.454	+2.545	<.001	<.001	3	2
SKCM	LINC02559 →	+0.094	+4.039	<.001	.009	3	2
UCEC	ALDOA →	+0.508	+3.609	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,002 associations by consensus.

RNU5E-9P by MKKS expression — UCEC

Explore this box plot interactively →