MKKS

Across TCGA pan-cancer cohorts, MKKS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MKKS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MKKS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MKKS is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where MKKS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKKS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.644	<.001	12	view →
THCA	All	IV	−1.192	<.001	10	view →
KIRC	Male	II,III,IV	−0.410	<.001	10	view →
LIHC	All	II,III,IV	+0.993	<.001	8	view →
STAD	All	II,III,IV	+0.726	<.001	8	view →
LUSC	Male	All	+0.712	<.001	5	view →
CHOL	All	All	+2.212	<.001	3	view →
BLCA	Female	All	+0.398	.023	3	view →
KIRP	Male	All	−0.346	.002	3	view →
READ	All	III,IV	+0.739	.035	2	view →
UCEC	All	IV	−0.369	.031	2	view →
PRAD	All	All	−0.283	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MKKS–HNSC

Open the HNSC breakdown →