MISP

Across TCGA cell cohorts, MISP mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MISP-associated genes across cancer lineages are GYS2, OR2D2, and KCNG4. Each is linked with MISP in more than 1 cancer types. Because this analysis shows association rather than direction, both MISP-to-partner and partner-to-MISP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYS2 grouped by MISP-low versus MISP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MISP→partner) and Y-score (partner→MISP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GYS2 →	+0.148	+3.954	<.001	.005	3	1
BLOOD_Lymphoma	OR2D2 →	+0.047	+4.115	<.001	.003	3	1
BLOOD_Lymphoma	KCNG4 →	+0.012	+3.927	.002	.004	3	1
BLOOD_Lymphoma	AGBL1 →	+0.013	+3.523	<.001	.009	3	1
SKIN	SNX32 →	+0.802	+3.364	<.001	.002	3	1
OVARY	SULT1C3 →	+0.192	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GYS2 by MISP expression — BLOOD_Lymphoma

Explore this box plot interactively →