MISP

Across TCGA pan-cancer cohorts, MISP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MISP data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MISP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MISP expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

LUAD, ACC, and PAAD are the cancer types where MISP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.735	0.843	<.001	72	view →
ACC	DFS	Median	All	0.829	0.394	<.001	56	view →
PAAD	DFS	Tertile	All	0.224	0.442	.003	38	view →
LUSC	DFS	Quartile	All	0.650	0.788	.003	33	view →
UCS	OS	Tertile	IV	0.932	0.405	.024	24	view →
KIRC	OS	Tertile	All	0.866	0.939	.004	21	view →
LAML	DFS	Median	All	0.505	0.261	.001	18	view →
SCLC	DFS	Quartile	All	0.706	0.448	.008	15	view →
READ	DFS	Tertile	IV	0.885	0.487	.021	12	view →
TGCT	DFS	Median	All	0.747	0.919	.009	12	view →
ESCA	OS	Tertile	All	0.481	1.000	.008	10	view →
SKCM	OS	Quartile	All	0.816	0.899	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MISP–LUAD (DFS)

Open the LUAD breakdown →