MIS18A

Across TCGA patient cohorts, MIS18A mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIS18A-associated genes across cancer lineages are RN7SKP61, RNU7-37P, and RNU6-1067P. Each is linked with MIS18A in more than 1 cancer types. Because this analysis shows association rather than direction, both MIS18A-to-partner and partner-to-MIS18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP61 grouped by MIS18A-low versus MIS18A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIS18A→partner) and Y-score (partner→MIS18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP61 →	+0.159	+7.954	<.001	.008	3	2
HNSC	RNU7-37P →	+0.578	+7.954	<.001	.008	3	2
CESC	RNU6-1067P →	+0.852	+6.569	<.001	.001	3	2
LUAD	MIR4535 →	+0.393	+7.930	<.001	.008	3	2
UCEC	PSAT1P4 →	+0.156	+2.978	.008	.001	3	2
UCEC	LINC00448 →	+0.065	+3.887	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

RN7SKP61 by MIS18A expression — HNSC

Explore this box plot interactively →