MIS18A

Across TCGA pan-cancer cohorts, MIS18A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MIS18A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MIS18A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIS18A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, HNSC, and COAD are the cancer types where MIS18A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIS18A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.035	<.001	11	view →
HNSC	Male	IV	+1.192	<.001	11	view →
COAD	All	III,IV	+1.031	<.001	11	view →
LUAD	Male	III,IV	+1.673	<.001	9	view →
LIHC	Female	II,III,IV	+1.448	<.001	9	view →
STAD	Female	All	+1.388	<.001	9	view →
LUSC	Female	II,III,IV	+2.331	<.001	8	view →
UCEC	All	III,IV	+1.509	<.001	6	view →
BRCA	All	III,IV	+1.212	<.001	6	view →
KIRP	All	II,III,IV	+0.570	.003	6	view →
CHOL	Male	All	+2.483	<.001	3	view →
ESCA	All	All	+1.333	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MIS18A–BLCA

Open the BLCA breakdown →