Across TCGA patient cohorts, MIR539 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MIR539-associated genes across cancer lineages are RN7SL541P, MRPL42P6, and RN7SL354P. Each is linked with MIR539 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR539-to-partner and partner-to-MIR539 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR539→partner) and Y-score (partner→MIR539) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL541P →	+0.140	+4.744	<.001	.001	3	1
SKCM	MRPL42P6 →	+0.113	+4.495	<.001	.007	3	1
SKCM	RN7SL354P →	+0.147	+4.403	.006	.002	3	1
SKCM	RN7SL849P →	+0.196	+4.551	.001	.001	3	1
SKCM	TRBV8-1 →	+0.087	+4.743	<.001	.005	3	1
UCEC	RDM1P2 →	+0.177	+6.226	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

MIR539 survival (RNA) · tumor vs normal (RNA) · all MIR539 data types