MIR4435-2

Across TCGA patient cohorts, MIR4435-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,429 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MIR4435-2-associated GO terms across cancer lineages are Positive regulation of ubiquitin-dependent protein catabolic process, Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, and Positive regulation of proteasomal protein catabolic process. Each is linked with MIR4435-2 in more than 10 cancer types. Because this analysis shows association rather than direction, both MIR4435-2-to-partner and partner-to-MIR4435-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ubiquitin-dependent protein catabolic process grouped by MIR4435-2-low versus MIR4435-2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR4435-2→partner) and Y-score (partner→MIR4435-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.044	+0.358	.001	<.001	3	11
LAML	Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.055	+1.090	<.001	<.001	2	11
ESCA	Positive regulation of proteasomal protein catabolic process →	+0.044	+0.421	.002	<.001	2	11
ESCA	Positive regulation of binding →	+0.044	+0.420	.003	<.001	2	11
ESCA	Vesicle budding from membrane →	+0.045	+0.349	.001	<.001	3	10
ESCA	DNA damage response, signal transduction by p53 class mediator →	+0.050	+0.393	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,429 associations by consensus.

Positive regulation of ubiquitin-dependent protein catabolic process by MIR4435-2 expression — ESCA

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