MIR4435-2

Across TCGA pan-cancer cohorts, MIR4435-2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated MIR4435-2 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher MIR4435-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR4435-2 expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

MESO, COAD, and LGG are the cancer types where MIR4435-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.237	0.440	.014	69	view →
COAD	OS	Tertile	IV	0.045	0.659	<.001	45	view →
LGG	OS	Tertile	All	0.390	0.815	.001	45	view →
UCS	OS	Tertile	III,IV	0.001	0.594	<.001	36	view →
ACC	OS	Tertile	All	0.268	0.802	.010	36	view →
KIRP	OS	Tertile	All	0.645	0.916	<.001	30	view →
LUAD	OS	Tertile	All	0.126	0.388	.022	27	view →
UVM	DFS	Tertile	All	0.180	0.744	.019	18	view →
UCEC	DFS	Tertile	All	0.802	0.898	.030	18	view →
CESC	OS	Tertile	All	0.741	0.884	.012	18	view →
BRCA	DFS	Tertile	III,IV	0.969	0.865	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MIR4435-2–MESO (DFS)

Open the MESO breakdown →