MIR4269

Across TCGA pan-cancer cohorts, MIR4269 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MIR4269’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MIR4269 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4269 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and HNSC are the cancer types where MIR4269 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4269 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.890	<.001	11	view →
COAD	Female	III,IV	−1.096	<.001	8	view →
HNSC	Male	IV	−1.126	.013	7	view →
UCEC	All	III,IV	−2.114	<.001	6	view →
BRCA	All	III,IV	−0.723	<.001	6	view →
READ	All	All	−2.036	<.001	5	view →
STAD	All	All	−1.226	<.001	5	view →
THCA	Male	IV	−0.726	<.001	5	view →
LUAD	Female	II,III,IV	−0.700	.010	4	view →
LUSC	All	All	−0.426	<.001	3	view →
PRAD	All	All	−0.504	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MIR4269–BLCA

Open the BLCA breakdown →