Q-omics provides the consensus-scored MIR378H profile across patient tissues and cancer cell-line models. MIR378H expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MIR378H is differentially expressed in 7, with the highest sampling consensus in THCA. Additionally, MIR378H RNA expression shows 16,344 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, THCA, and THYM as cancer lineages where MIR378H shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR378H — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR378H survival associations across molecular data types. MIR378H RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR378H RNA expression–survival associations across cancer types. High MIR378H expression shows unfavorable associations in UCEC and LGG, but favorable associations in HNSC, KIRP, UCS and GBM. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .005). Together, the overview and detailed table identify HNSC as the clearest survival context for MIR378H RNA expression.
This table summarizes MIR378H tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MIR378H. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR378H shows lower tumor expression in THCA, LUSC and BRCA and higher tumor expression in LIHC, BLCA and KIRC. The THCA box plot shows higher MIR378H RNA expression in normal versus tumor tissue (log2 FC = −0.775, t-test p < 0.001).
This table shows molecular features associated with MIR378H in patient tissues and cancer cell lines. In patient samples, MIR378H shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
