MIR1-1HG

Across TCGA patient cohorts, MIR1-1HG mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible MIR1-1HG-associated genes across cancer lineages are SMIM34B, RNA5SP485, and MIR132. Each is linked with MIR1-1HG in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR1-1HG-to-partner and partner-to-MIR1-1HG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM34B grouped by MIR1-1HG-low versus MIR1-1HG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR1-1HG→partner) and Y-score (partner→MIR1-1HG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMIM34B →	+0.029	+7.816	<.001	.008	3	2
BLCA	RNA5SP485 →	+0.358	+7.640	<.001	.009	3	1
UCEC	MIR132 →	+0.650	+5.771	<.001	.003	3	1
SKCM	RNF138P2 →	+0.049	+7.816	<.001	.008	3	1
SKCM	PRAMEF34P →	+0.019	+7.816	<.001	.008	3	1
LUSC	RNA5SP509 →	+0.373	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SMIM34B by MIR1-1HG expression — SKCM

Explore this box plot interactively →