MIR1-1HG

Across TCGA pan-cancer cohorts, MIR1-1HG RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MIR1-1HG’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MIR1-1HG RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1-1HG is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and HNSC are the cancer types where MIR1-1HG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR1-1HG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−0.601	<.001	11	view →
COAD	All	II,III,IV	−0.213	<.001	10	view →
HNSC	Male	All	−1.642	.001	8	view →
STAD	All	All	−0.411	<.001	6	view →
UCEC	All	All	−0.274	<.001	6	view →
READ	All	All	−0.484	.004	2	view →
PRAD	All	All	−0.265	.017	2	view →
CHOL	All	All	+0.041	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MIR1-1HG–BLCA

Open the BLCA breakdown →