MIR1-1HG

Across TCGA pan-cancer cohorts, MIR1-1HG RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MIR1-1HG data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MIR1-1HG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR1-1HG expression acts as an unfavorable survival marker, although some lineages such as BRCA and STAD show a favorable association.

HNSC, KICH, and KIRC are the cancer types where MIR1-1HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.282	0.426	<.001	88	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	54	view →
KIRC	OS	Tertile	All	0.723	0.821	.003	42	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
THCA	OS	Tertile	All	0.934	0.979	.002	33	view →
OV	OS	Tertile	All	0.754	0.863	.015	30	view →
LUAD	DFS	Tertile	IV	0.366	0.742	.038	27	view →
BRCA	OS	Tertile	III,IV	1.000	0.815	.026	27	view →
SKCM	DFS	Tertile	II,III,IV	0.120	0.332	.013	21	view →
STAD	DFS	Tertile	IV	0.670	0.250	.027	18	view →
BLCA	DFS	Tertile	III,IV	0.540	0.284	.014	18	view →
UVM	OS	Tertile	All	0.589	0.943	.027	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MIR1-1HG–HNSC (OS)

Open the HNSC breakdown →