MINK1

Across TCGA cell cohorts, MINK1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MINK1-associated genes across cancer lineages are GML, LGI1, and TMPRSS7. Each is linked with MINK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINK1-to-partner and partner-to-MINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by MINK1-low versus MINK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINK1→partner) and Y-score (partner→MINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.099	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.067	+4.276	<.001	.007	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PRR30 →	+0.013	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR4E2 →	+1.052	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GML by MINK1 expression — BLOOD_Leukemia

Explore this box plot interactively →