MIDEAS

Across TCGA patient cohorts, MIDEAS RNA expression is significantly associated with the protein abundance of many other proteins, with 12,594 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MIDEAS-associated proteins across cancer lineages are DNTTIP1, SPCS3, and SEC23B. Each is linked with MIDEAS in more than 6 cancer types. Because this analysis shows association rather than direction, both MIDEAS-to-partner and partner-to-MIDEAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MIDEAS versus DNTTIP1 in BRCA, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDEAS→partner) and Y-score (partner→MIDEAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNTTIP1 →	+0.368	+0.776	<.001	<.001	3	7
LUAD	SPCS3 →	-0.487	-0.481	.002	<.001	3	5
LUAD	SEC23B →	-0.329	-0.469	<.001	<.001	3	4
BRCA	ATXN3 →	+0.299	+0.709	<.001	<.001	3	4
PDAC	DCAF5_S648 →	+0.541	+0.379	.001	.001	3	4
LSCC	FKBP11 →	-0.667	-0.433	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,594 associations by consensus.

MIDEAS vs DNTTIP1 — BRCA

Explore this scatter interactively →