MIDEAS

Across TCGA pan-cancer cohorts, MIDEAS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MIDEAS data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MIDEAS RNA is associated with better overall survival. In most high-consensus cancer types, elevated MIDEAS expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and ACC are the cancer types where MIDEAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.951	0.896	<.001	84	view →
KIRC	OS	Tertile	All	0.744	0.565	<.001	66	view →
ACC	DFS	Tertile	All	0.232	0.726	<.001	61	view →
OV	OS	Median	All	0.263	0.374	.001	26	view →
UVM	DFS	Median	II,III,IV	0.345	0.634	.004	22	view →
LUSC	DFS	Median	III,IV	0.407	0.883	.006	18	view →
CHOL	DFS	Median	All	0.660	0.189	.003	17	view →
UCS	DFS	Tertile	IV	0.978	0.364	.024	12	view →
SKCM	DFS	Quartile	II,III,IV	0.799	0.660	.010	11	view →
SCLC	DFS	Tertile	II,III,IV	1.000	0.432	.006	9	view →
BLCA	DFS	Quartile	All	0.277	0.667	.007	9	view →
UCEC	DFS	Tertile	All	0.661	0.789	.021	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MIDEAS–BRCA (OS)

Open the BRCA breakdown →