MIDEAS

Across TCGA pan-cancer cohorts, MIDEAS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MIDEAS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIDEAS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIDEAS is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where MIDEAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIDEAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.951	<.001	9	view →
COAD	Female	III,IV	−0.947	<.001	8	view →
BLCA	Male	All	−0.575	.014	5	view →
LUAD	Female	All	−0.539	<.001	5	view →
THCA	All	All	−0.445	<.001	4	view →
LUSC	All	All	−0.381	<.001	4	view →
UCEC	All	All	−0.595	.012	2	view →
PAAD	Male	All	+0.355	.019	2	view →
CHOL	All	All	+0.835	.026	1	view →
READ	All	All	−0.773	.007	1	view →
KIRC	All	All	+0.218	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MIDEAS–HNSC

Open the HNSC breakdown →