MIDEAS

Across TCGA patient cohorts, MIDEAS mutation is significantly associated with the RNA expression of many other genes, with 5,412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIDEAS-associated genes across cancer lineages are CCNB2, PGAM5, and HPRT1. Each is linked with MIDEAS in more than 3 cancer types. Because this analysis shows association rather than direction, both MIDEAS-to-partner and partner-to-MIDEAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by MIDEAS-low versus MIDEAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDEAS→partner) and Y-score (partner→MIDEAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.720	+2.807	<.001	<.001	3	4
UCEC	PGAM5 →	+0.604	+2.502	<.001	<.001	3	4
UCEC	HPRT1 →	+0.472	+1.848	<.001	<.001	3	4
UCEC	CHAF1A →	+0.635	+2.258	<.001	<.001	3	4
COAD	CTDNEP1 →	+0.373	+2.713	.004	.003	3	4
UCEC	DEPDC1 →	+0.737	+2.818	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,412 associations by consensus.

CCNB2 by MIDEAS expression — UCEC

Explore this box plot interactively →