MIDEAS

Across TCGA patient cohorts, MIDEAS mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIDEAS-associated genes across cancer lineages are ASNS, MEK1, and Rad50. Each is linked with MIDEAS in more than 2 cancer types. Because this analysis shows association rather than direction, both MIDEAS-to-partner and partner-to-MIDEAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MIDEAS-low versus MIDEAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDEAS→partner) and Y-score (partner→MIDEAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.255	+1.362	.025	.034	3	3
UCEC	MEK1 →	+0.487	+2.432	<.001	<.001	3	2
COAD	Rad50 →	-0.283	-2.974	.006	.035	3	2
COAD	Chk2_pT68 →	-0.142	-2.433	.047	.020	3	2
UCEC	eIF4E →	+0.177	+2.428	.007	.001	3	2
UCEC	ERK2 →	+0.145	+1.678	.016	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by MIDEAS expression — UCEC

Explore this box plot interactively →