MIDEAS

Across TCGA cell cohorts, MIDEAS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIDEAS-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Endosomal transport, and Regulatory ncRNA-mediated gene silencing. Each is linked with MIDEAS in more than 14 cancer types. Because this analysis shows association rather than direction, both MIDEAS-to-partner and partner-to-MIDEAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by MIDEAS-low versus MIDEAS-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDEAS→partner) and Y-score (partner→MIDEAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.053	+1.158	<.001	<.001	3	15
BREAST	Endosomal transport →	+0.058	+0.913	<.001	<.001	3	14
URINARY_TRACT	Regulatory ncRNA-mediated gene silencing →	+0.071	+0.887	<.001	.001	3	14
URINARY_TRACT	miRNA processing →	+0.078	+0.918	.008	.005	3	14
OESOPHAGUS	mRNA 5'-splice site recognition →	+0.133	+0.761	.007	.009	3	14
KIDNEY	Peptidyl-serine modification →	+0.078	+1.140	.002	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,281 associations by consensus.

Phosphatidylinositol metabolic process by MIDEAS expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →