MIDEAS

Across TCGA cell cohorts, MIDEAS mutation is significantly associated with the RNA expression of many other genes, with 1,801 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIDEAS-associated genes across cancer lineages are OR1L3, C14orf177, and GPR139. Each is linked with MIDEAS in more than 2 cancer types. Because this analysis shows association rather than direction, both MIDEAS-to-partner and partner-to-MIDEAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by MIDEAS-low versus MIDEAS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDEAS→partner) and Y-score (partner→MIDEAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	C14orf177 →	+0.026	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GPR139 →	+0.076	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	DGKK →	+0.006	+5.357	<.001	.003	3	2
LARGE_INTESTINE	KSR2 →	+0.506	+3.850	<.001	<.001	3	2
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,801 associations by consensus.

OR1L3 by MIDEAS expression — SKIN

Explore this box plot interactively →