MICAL3

Across TCGA cell cohorts, MICAL3 mutation is significantly associated with the RNA expression of many other genes, with 1,752 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MICAL3-associated genes across cancer lineages are DNAJC27, SLC39A6, and ZNF324B. Each is linked with MICAL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MICAL3-to-partner and partner-to-MICAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC27 grouped by MICAL3-low versus MICAL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICAL3→partner) and Y-score (partner→MICAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAJC27 →	+0.532	+3.321	.003	.005	3	4
LARGE_INTESTINE	SLC39A6 →	+0.929	+2.523	<.001	.003	3	3
BLOOD_Leukemia	ZNF324B →	+0.492	+2.674	.004	.003	3	3
BLOOD_Leukemia	MARK4 →	+0.661	+3.321	.002	.005	3	3
BLOOD_Leukemia	E2F2 →	+1.314	+2.614	.001	.003	3	3
LARGE_INTESTINE	RNF125 →	+0.839	+2.949	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,752 associations by consensus.

DNAJC27 by MICAL3 expression — BLOOD_Leukemia

Explore this box plot interactively →