MICAL3

Across TCGA pan-cancer cohorts, MICAL3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MICAL3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MICAL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MICAL3 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where MICAL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MICAL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.338	<.001	12	view →
KIRC	Female	All	+1.024	<.001	11	view →
THCA	Female	II,III,IV	−1.079	<.001	10	view →
COAD	Female	II,III,IV	−0.611	<.001	7	view →
UCEC	All	All	−1.003	<.001	6	view →
BRCA	All	III,IV	−0.973	<.001	6	view →
KIRP	All	II,III,IV	+0.643	.014	6	view →
LIHC	All	All	+0.506	<.001	6	view →
LUSC	Male	All	+1.245	<.001	5	view →
CHOL	All	All	+1.055	.001	4	view →
LUAD	All	All	+0.428	<.001	4	view →
BLCA	Male	IV	−1.095	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MICAL3–HNSC

Open the HNSC breakdown →