MGRN1

Across TCGA patient cohorts, MGRN1 mutation is significantly associated with the RNA expression of many other genes, with 2,824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGRN1-associated genes across cancer lineages are SAP30, IGHD5-24, and GTF2IP2. Each is linked with MGRN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MGRN1-to-partner and partner-to-MGRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAP30 grouped by MGRN1-low versus MGRN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGRN1→partner) and Y-score (partner→MGRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAP30 →	+0.555	+3.606	.001	.001	3	3
READ	IGHD5-24 →	+1.162	+5.219	<.001	.006	3	2
READ	GTF2IP2 →	+0.134	+6.257	<.001	.001	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
READ	MIR6752 →	+0.786	+5.421	<.001	.005	3	2
UCEC	TMEM263 →	+0.578	+2.839	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,824 associations by consensus.

SAP30 by MGRN1 expression — UCEC

Explore this box plot interactively →