MGRN1

Across TCGA pan-cancer cohorts, MGRN1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MGRN1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MGRN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MGRN1 expression acts as an unfavorable survival marker, although some lineages such as UVM and SARC show a favorable association.

LUSC, UVM, and SARC are the cancer types where MGRN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	All	0.269	0.481	.003	49	view →
UVM	DFS	Tertile	III,IV	0.771	0.216	.009	43	view →
SARC	DFS	Tertile	All	0.645	0.368	.001	23	view →
PAAD	DFS	Tertile	All	0.551	0.304	.001	23	view →
KIRP	DFS	Tertile	IV	0.469	0.800	.010	18	view →
UCEC	DFS	Median	III,IV	0.685	0.448	.016	18	view →
BRCA	OS	Quartile	IV	0.669	0.204	.030	12	view →
SCLC	DFS	Median	All	0.398	0.207	.014	12	view →
ACC	DFS	Median	All	0.557	0.757	.007	10	view →
THCA	DFS	Median	IV	0.581	0.984	.003	10	view →
HNSC	DFS	Tertile	IV	0.440	0.288	.015	9	view →
KIRC	DFS	Median	IV	0.756	0.488	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MGRN1–LUSC (DFS)

Open the LUSC breakdown →