MGRN1

Across TCGA pan-cancer cohorts, MGRN1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MGRN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MGRN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MGRN1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where MGRN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGRN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.213	<.001	12	view →
KIRP	All	IV	+1.360	<.001	11	view →
COAD	Female	All	+0.804	<.001	10	view →
STAD	Male	II,III,IV	+1.003	<.001	8	view →
HNSC	All	All	+0.375	<.001	8	view →
BRCA	All	III,IV	+0.762	<.001	6	view →
LUSC	Male	All	−0.645	<.001	6	view →
LIHC	Female	All	+0.603	<.001	6	view →
READ	All	All	+0.416	.007	4	view →
CHOL	Male	All	+1.280	<.001	3	view →
THCA	All	All	+0.266	.003	3	view →
PRAD	All	All	+0.251	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MGRN1–KIRC

Open the KIRC breakdown →