MGRN1

Across TCGA patient cohorts, MGRN1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGRN1-associated genes across cancer lineages are mTOR_pS2448, TFRC, and ATM. Each is linked with MGRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGRN1-to-partner and partner-to-MGRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MGRN1-low versus MGRN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGRN1→partner) and Y-score (partner→MGRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.148	-1.986	.009	.029	3	2
UCEC	TFRC →	+0.482	+1.678	.018	.023	3	2
UCEC	ATM →	-0.672	-2.700	<.001	.006	3	2
UCEC	4E-BP1 →	+0.415	+3.700	<.001	.001	3	2
UCEC	eIF4E →	+0.184	+2.087	.022	.005	2	2
UCEC	ERK2 →	+0.234	+1.678	.001	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by MGRN1 expression — UCEC

Explore this box plot interactively →