MGRN1

Across TCGA cell cohorts, MGRN1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGRN1-associated genes across cancer lineages are CCR8, BHLHA9, and GOLGA6L6. Each is linked with MGRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGRN1-to-partner and partner-to-MGRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by MGRN1-low versus MGRN1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGRN1→partner) and Y-score (partner→MGRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	BHLHA9 →	+0.036	+5.977	<.001	.001	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.013	+5.369	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	MAGEA9 →	+0.655	+4.209	.004	.006	3	1
BLOOD_Leukemia	LCN1 →	+0.030	+4.922	.002	.009	3	1
BLOOD_Leukemia	PRM3 →	+0.090	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CCR8 by MGRN1 expression — SOFT_TISSUE

Explore this box plot interactively →