MGAT4B

Across TCGA patient cohorts, MGAT4B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT4B-associated genes across cancer lineages are MSH6, A-Raf_pS299, and ERK2. Each is linked with MGAT4B in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT4B-to-partner and partner-to-MGAT4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by MGAT4B-low versus MGAT4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT4B→partner) and Y-score (partner→MGAT4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.444	-2.584	<.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.148	-2.000	.002	.030	3	1
UCEC	ERK2 →	+0.179	+2.459	.020	.018	3	1
UCEC	INPP4B →	-0.329	-3.459	.011	.005	3	1
UCEC	MEK1 →	+0.403	+1.906	.006	.016	3	1
UCEC	MSH2 →	-0.227	-1.990	.014	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH6 by MGAT4B expression — UCEC

Explore this box plot interactively →