MGAT4B

Across TCGA pan-cancer cohorts, MGAT4B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MGAT4B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MGAT4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MGAT4B is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

KIRP, BLCA, and THCA are the cancer types where MGAT4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGAT4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.897	<.001	11	view →
BLCA	Male	III,IV	+1.395	<.001	11	view →
THCA	Male	III,IV	+1.071	<.001	11	view →
KIRC	Female	All	+0.812	<.001	11	view →
LIHC	Male	All	+0.994	<.001	9	view →
KICH	Female	All	+0.706	<.001	9	view →
HNSC	Male	All	+0.663	<.001	9	view →
LUAD	All	III,IV	+0.652	<.001	9	view →
STAD	Male	II,III,IV	+1.270	<.001	6	view →
BRCA	All	III,IV	+0.635	<.001	6	view →
CHOL	All	All	+1.008	<.001	3	view →
ESCA	All	II,III,IV	+1.695	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MGAT4B–KIRP

Open the KIRP breakdown →